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Unlocking Confidence in Clinical Trial Design: A Comprehensive Guide to Sample Size Guidelines

Jayson Powell

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Published in CRC Handbook Of Sample Size Guidelines For Clinical Trials: CRC Handbook Of Sample Size Guidelines For Clinical Trials (1990) (CRC Press Revivals)

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Clinical trials are pivotal in the advancement of medical knowledge and the development of new treatments. However, determining the optimal sample size for a clinical trial is a critical yet challenging task that can impact the validity and reliability of the results.

The CRC Handbook of Sample Size Guidelines for Clinical Trials provides a comprehensive and practical guide to help researchers, clinicians, and statisticians navigate the complexities of sample size determination. This invaluable resource offers:

CRC Handbook of Sample Size Guidelines for Clinical Trials: CRC Handbook of Sample Size Guidelines for Clinical Trials (1990) (CRC Press Revivals)

by Jonathan J. Shuster

4.8 out of 5

Language	:	English
File size	:	186638 KB
Screen Reader	:	Supported
Print length	:	862 pages

In-depth coverage of statistical concepts underlying sample size calculations, empowering readers with a strong foundation
Step-by-step guidance for calculating sample sizes for various study designs and endpoints
Discussion of advanced techniques for addressing complex scenarios, such as adaptive designs and rare events
Tables, graphs, and software recommendations for efficient sample size determination

Chapter 1: Foundations of Sample Size Determination

This chapter introduces the fundamental statistical concepts essential for understanding sample size guidelines. It covers:

Hypothesis testing and statistical power
Type I and type II errors
Confidence intervals and precision
Assumptions and limitations of sample size calculations

Chapter 2: Sample Size Guidelines for Common Study Designs

Chapter 2 focuses on practical guidance for determining sample sizes for a wide range of study designs, including:

Two-group parallel designs for comparing interventions or treatments
Crossover designs for evaluating multiple treatments in a single group of participants
Matched-pair designs for controlling for confounding variables
Cluster-randomized trials for assessing interventions at the group level

Chapter 3: Advanced Techniques for Complex Scenarios

For complex research questions, Chapter 3 delves into advanced techniques for sample size determination:

Adaptive designs that allow for modifications during the trial
Sequential designs that provide ongoing analysis and decision-making
Sample size re-estimation for adjusting sample sizes based on interim data
Rare events and the challenges of estimating sample sizes

Chapter 4: Tools and Resources for Sample Size Determination

Chapter 4 provides practical tools and resources to aid in sample size determination:

Tables and graphs for quick reference and estimation
Software recommendations for automated calculations
Online calculators for convenient access to sample size estimates

The CRC Handbook of Sample Size Guidelines for Clinical Trials is an essential resource for anyone involved in the design and conduct of clinical trials.

By providing comprehensive guidance, practical tools, and advanced techniques, this handbook empowers researchers to make informed decisions about sample sizes, ensuring the validity and reliability of their research findings.

With this invaluable guide in hand, clinicians and statisticians can navigate the complexities of sample size determination with confidence, maximizing the precision and impact of their clinical trials.

CRC Handbook of Sample Size Guidelines for Clinical Trials: CRC Handbook of Sample Size Guidelines for Clinical Trials (1990) (CRC Press Revivals)

by Jonathan J. Shuster

4.8 out of 5